Using Sglt 2 Inhibitors With Insulin Essay - 729 Words

USING SGLT-2 INHIBITORS WITH INSULIN IN TYPE 2 DIABETES: CLINICAL IMPLICATIONS Mathew John, Deepa Gopinath Introduction Diabetes and its complications account for significant healthcare costs in developed countries. The control of hyperglycemia forms the cornerstone in managing diabetes. United Kingdom Prospective Diabetes Study (UKPDS) has shown that improving blood sugars can result in reduction in onset of retinopathy, microalbuminuria and neuropathy. Follow up of the subjects in UKPDS after 10 years have shown a distinct improvement in outcomes like mortality, microvascular disease and macrovascular disease in subjects who were intensively controlled. Various classes of oral anti diabetic agents, insulin and GLP-1 agonists form the armamentarium against hyperglycaemia. Despite the availability of these agents, the overall control of hyperglycaemia remains suboptimal. Sodium linked Glucose Co- Transporter-2 (SGLT-2) inhibitors form a new class of agents that act on the kidney by competitively blocking the SGLT-2 channels. These agents are approved by FDA to be used as monotherapy or in combination with Metformin, Sulphonylurea (SU), Pioglitazone, or insulin. The ADA practice guidelines have added SGLT-2 inhibitors as the first add on to Metformin along with other drugs like SU, Dipeptyl Peptidase 4 (DPP4) inhibitors, thiazolidinedione and basal insulin. SGLT-2 inhibitors also finds a place as a second add on drug after 2 of the other drugs areShow MoreRelatedDiabetes Type 2 Meta Analysis1011 Words   |  5 PagesDiabetes Type 2 meta-analysis Abstract Objective To compare treatment options of type2 diabetes. In reference to this a systematic review and meta-analysis of controlled trials, observation-based studies and published information was carried out in an attempt to investigate the difference of efficacy between pharmacologic treatment in Diabetes type 2, specifically the newer oral class known as the SGLT-2 Inhibitors. Research designs and methods A literature search was conducting using the keywordsRead MoreThe Effect Of Empagliflozin ( Jardiance ), An Inhibitor Of Sodium Glucose Cotransporter 2944 Words   |  4 Pagesempagliflozin(JARDIANCE), an inhibitor of sodium–glucose cotransporter 2, in addition to standard care, on cardiovascular morbidity and mortality in patients with type 2 diabetes at high cardiovascular risk. Background According to the International Diabetes Federation (IDF), more than 371 million people across the globe have diabetes and this figure is predicted to rise to over 550 million by 2030. Type 2 diabetes occurs when the hormone insulin is not used effectively by theRead MoreDiabetes : The Most Common Type Of Diabetes2258 Words   |  10 PagesDiabetes is an endocrine disorder characterized by elevated glucose due to insulin resistance or deficiency. About 29.1 million people in America are reported to have diabetes with the highest prevalence occurring in men; about 25.9% of adults 65 years and older have diabetes.1 Type 2 diabetes (T2DM) is the most common type of diabetes, often due to insulin resistance. Metformin is the treatment of choice in patients with T2DM, a second agent such as a sulfonylurea is added to metformin in patients